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In contrast, modified revTetR repressors of the present invention comprising the amino acid substitution of asparagine for isoleucine for position 59, but comprising different substitutions of arginine for lysine at position 98, histidine for leucine at position 101 and glycine for serine at position 192 (eg, SEQ ID NO. Hypersensitivity to sulfonamide-derived drugs and hypokalaemia might occur!

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